Description

Mecilizine CAS NO 163837-49-8 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the piperazine derivative class. It is a critical compound valued for its antihistaminic and antiemetic properties, essential for ensuring the efficacy and safety of final drug formulations. This product is primarily required by manufacturers in the pharmaceutical industry for the development and production of anti-vertigo and anti-nausea medications.

Application

• Pharmaceutical API Synthesis: Primary use as an active ingredient in the manufacture of prescription anti-vertigo medications.
• Antiemetic Formulations: Key component in drugs developed to prevent and treat nausea and vomiting, including motion sickness.
• Research & Development: Serves as a reference standard and building block in pharmacological research for central nervous system (CNS) agents.
• Veterinary Pharmaceuticals: Used in formulations to treat motion sickness and vestibular disorders in animals.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded meclizine-based therapeutics.
• Preclinical Studies: Utilized in laboratory studies to investigate mechanisms of action and therapeutic efficacy.

Basic Information

Product Name	Mecilizine
CAS No.	163837-49-8
Molecular Formula	C25H27ClN2
Molecular Weight	390.95 g/mol
Synonyms	Meclizine; Meclozine; Postafen; Bonine; Antivert; 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine; 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; Histametizine
EINECS	Contact for details

Quality Control

Our Mecilizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.