Description

Hydroxyzine Hydrochloride is a high-purity pharmaceutical active ingredient, a first-generation antihistamine of the piperazine class. Its primary value lies in its reliable efficacy as a sedating antihistamine and anxiolytic agent for pharmaceutical formulation. This compound is essential for manufacturers in the pharmaceutical industry developing prescription medications for anxiety, pruritus, and as a pre-operative sedative.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of prescription tablets, capsules, and syrups.
• Anxiolytic Formulations: Used in medications for the short-term management of anxiety and tension.
• Antipruritic Medications: Key ingredient in treatments for itching caused by allergic conditions, chronic urticaria, and atopic dermatitis.
• Pre-Medication Sedative: Employed in pre- and post-operative settings to alleviate anxiety and provide sedation.
• Antiemetic Adjunct Therapy: Used in combination with other agents to help control nausea and vomiting.
• Research & Development: Serves as a reference standard and starting material in pharmacological research and new drug development.

Basic Information

Product Name	Hydroxyzine Hydrochloride
CAS No.	163837-38-5
Molecular Formula	C21H27ClN2O2 • HCl
Molecular Weight	447.82 g/mol
Synonyms	Hydroxyzine HCl; 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride; Atarax (trade name); Vistaril (trade name); 1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine Dihydrochloride; (±)-Hydroxyzine Hydrochloride
EINECS	Contact for details

Quality Control

Our Hydroxyzine Hydrochloride is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with pharmaceutical-grade standards, including identity, purity, and impurity profile verification. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.