Description

Hydroxyzine Hydrochloride is a high-purity pharmaceutical active ingredient, a first-generation antihistamine of the piperazine class. It is a critical intermediate and active pharmaceutical ingredient (API) valued for its potent antiemetic, anxiolytic, and sedative properties. This compound is essential for manufacturers in the pharmaceutical industry producing finished dosage forms for the treatment of anxiety, pruritus, and as a premedication before surgery.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablet, capsule, and syrup formulations.
• Anxiolytic Medications: Manufacture of prescription drugs for the management of anxiety and tension.
• Antipruritic Agents: Key component in medications designed to relieve itching caused by allergic conditions.
• Preoperative Sedation: Used in pharmaceutical preparations administered to sedate patients before anesthesia.
• Antiemetic Formulations: Incorporated into drugs that prevent nausea and vomiting.
• Research & Development: Serves as a reference standard and building block in pharmacological and medicinal chemistry research.

Basic Information

Product Name	Hydroxyzine Hydrochloride
CAS No.	163837-37-4
Molecular Formula	C21H27ClN2O2 • HCl
Molecular Weight	447.82 g/mol
Synonyms	Hydroxyzine HCl; 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride; Atarax (brand name); Vistaril (brand name); 1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine Dihydrochloride; (±)-Hydroxyzine Hydrochloride
EINECS	Contact for details

Quality Control

Our Hydroxyzine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.