Description

Mecilizine Hydrochloride CAS NO 163837-34-1 is a high-purity pharmaceutical active ingredient belonging to the class of piperazine derivatives. This compound is critical for its potent antihistaminic and antiemetic properties, making it a key component in the formulation of effective medications. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of treatments for motion sickness, vertigo, and nausea.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of prescription and over-the-counter (OTC) antiemetic and antivertigo medications.
• Motion Sickness Tablets/Capsules: Core component in drugs designed to prevent and treat nausea, vomiting, and dizziness associated with travel.
• Vertigo Management: Used in therapeutic products targeting conditions like Ménière's disease and other vestibular disorders.
• Veterinary Pharmaceuticals: Application in veterinary medicine for managing motion sickness and vestibular symptoms in animals.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and new drug development.
• Dosage Form Development: Utilized in the development of various dosage forms including tablets, chewable tablets, and orally disintegrating films.

Basic Information

Product Name	Mecilizine Hydrochloride
CAS No.	163837-34-1
Molecular Formula	C25H27ClN2 • HCl
Molecular Weight	463.86 g/mol
Synonyms	Meclizine Hydrochloride; Meclozine Hydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride; Postafen; Bonine; Antivert; Dramamine Less Drowsy; Histametizyne Hydrochloride; Calmonal
EINECS	Contact for details

Quality Control

Our Mecilizine Hydrochloride is manufactured under strict quality control systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing parameters such as assay, related substances, residual solvents, and identification. We adhere to cGMP guidelines to ensure supply reliability and batch-to-batch consistency for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.