Description

Mecilizine Hydrochloride is a high-purity pharmaceutical active ingredient, also known as Meclizine Hydrochloride, widely recognized for its potent antihistaminic and antiemetic properties. This compound is critical for the formulation of reliable and effective medications that manage vertigo, motion sickness, and nausea. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare sector. Consistent quality and reliable supply are paramount for its integration into final dosage forms.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of prescription and over-the-counter (OTC) medications for vertigo and dizziness.
• Antiemetic Formulations: Key component in drugs designed to prevent and treat nausea and vomiting associated with motion sickness.
• Vestibular Disorder Treatments: Used in therapies for conditions affecting the inner ear and balance system.
• Research & Development: Serves as a reference standard and building block in pharmacological and clinical studies.
• Veterinary Pharmaceuticals: Applicable in formulations for managing motion sickness and vestibular syndromes in animals.
• Fine Chemical Intermediate: Used in the synthesis of more complex chemical entities in specialized organic chemistry.

Basic Information

Product Name	Mecilizine Hydrochloride
CAS No.	163837-33-0
Molecular Formula	C25H27ClN2 • 2HCl
Molecular Weight	463.87 g/mol (for dihydrochloride salt)
Synonyms	Meclizine Hydrochloride; Meclozine Hydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride; Bonamine; Antivert; Postafen; Dramamine II; Calmonal; Itinerol; Vergon; Histametizyne; CB-313
EINECS	Contact for details

Quality Control

Our Mecilizine Hydrochloride is manufactured and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards, with specifications typically aligned with major pharmacopoeial guidelines. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.