Description

2-((3-Trifluoromethyl)Phenyl)Histamine D is a specialized histamine derivative featuring a trifluoromethylphenyl substituent, a structural motif of significant interest in advanced pharmaceutical research and development. This compound is valued for its potential as a key synthetic intermediate or a pharmacologically active scaffold in the design of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for programs targeting central nervous system (CNS) disorders, inflammation, or allergic responses where histaminergic pathways are implicated.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates targeting histamine receptors (H1-H4).
• Medicinal Chemistry Research: Used as a reference standard or a core scaffold for structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Biochemical Tool Compound: Employed in vitro and in vivo studies to investigate the role of histaminergic systems in physiological and pathological processes.
• High-Throughput Screening (HTS): Included in compound libraries for screening campaigns to identify new leads for CNS, anti-inflammatory, or anti-allergy therapeutics.
• Process Chemistry Development: Used in the development and optimization of scalable synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-((3-Trifluoromethyl)Phenyl)Histamine D
CAS No.	162049-83-4
Molecular Formula	C12H12F3N3
Molecular Weight	255.24 g/mol
Synonyms	2-(3-(Trifluoromethyl)phenyl)histamine; 2-[3-(Trifluoromethyl)phenyl]-1H-imidazole-4-ethanamine; 1H-Imidazole-4-ethanamine, 2-[3-(trifluoromethyl)phenyl]-; Histamine, 2-(3-trifluoromethylphenyl)-; α-(3-Trifluoromethylphenyl)histamine; 2-(α,α,α-Trifluoro-m-tolyl)histamine; 2-(3-Trifluorophenyl)histamine
EINECS	Contact for details

Quality Control

Our 2-((3-Trifluoromethyl)Phenyl)Histamine D is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.