Description

2,2-Difluorobenzo[D][1,3]Dioxole-4-Carbonitrile is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoromethylene-dioxole moiety and the versatile nitrile group, enabling precise molecular construction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify dielectric properties and stability.
• Fluorine Chemistry Building Block: Provides a versatile platform for further functionalization via the nitrile group (hydrolysis, reduction, cycloaddition) in discovery chemistry.

Basic Information

Product Name	2,2-Difluorobenzo[D][1,3]Dioxole-4-Carbonitrile
CAS No.	161886-18-6
Molecular Formula	C8H3F2NO2
Molecular Weight	183.11 g/mol
Synonyms	4-Cyano-2,2-difluorobenzo[d][1,3]dioxole; 2,2-Difluoro-1,3-benzodioxole-4-carbonitrile; 2,2-Difluorobenzo-1,3-dioxole-4-carbonitrile; 4-CN-2,2-DFBD; Difluorobenzodioxolecarbonitrile; 161886-18-6; Benzo[d][1,3]dioxole-4-carbonitrile, 2,2-difluoro-
EINECS	Contact for details

Quality Control

Our 2,2-Difluorobenzo[D][1,3]Dioxole-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F), and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.