Description

Halcinonide is a potent synthetic corticosteroid belonging to the glucocorticoid class, widely recognized for its significant anti-inflammatory and immunosuppressive properties. Its primary commercial value lies in its efficacy as a key active pharmaceutical ingredient (API) in topical dermatological formulations designed to treat severe inflammatory skin conditions. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors developing prescription-strength creams, ointments, and lotions. Halcinonide CAS NO 161491-04-9 offers a reliable solution for formulators requiring a high-potency corticosteroid with a well-established clinical profile.

Application

• Topical Corticosteroid Formulations: Primary use as the active ingredient in prescription creams, ointments, gels, and lotions for treating severe eczema, psoriasis, and dermatitis.
• Dermatological Research: Serves as a reference standard and key intermediate in pharmacological research focused on anti-inflammatory mechanisms and new topical drug delivery systems.
• Pharmaceutical Intermediates: Used in the synthesis of more complex steroid molecules and specialized corticosteroid derivatives within fine chemical manufacturing.
• Veterinary Medicine: Incorporated into topical preparations for managing inflammatory skin conditions in animals under veterinary supervision.

Basic Information

Product Name	Halcinonide
CAS No.	161491-04-9
Molecular Formula	C₂₄H₃₂ClFO₆
Molecular Weight	454.96 g/mol
Synonyms	21-Chloro-9-fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; Halog; SQ-18566; 21-Chloro-9-fluoro-11β-hydroxy-16α,17-(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; Halcimonide; Halcinonidum
EINECS	Contact for details

Quality Control

Our Halcinonide is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with cGMP guidelines. We are committed to supplying material that consistently meets or exceeds pharmacopeial specifications for identity, strength, quality, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.