Description

D-Proline, 4-Fluoro-5-Oxo-, (4R)- (9Ci) CAS NO 160705-72-6 is a high-purity, non-natural amino acid derivative featuring a specific stereochemistry (4R) and a fluorinated oxo-pyrrolidine structure. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates to create complex, targeted compounds with specific biological activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that leverage its unique fluorinated proline scaffold.
• Peptidomimetics & Drug Design: Serves as a constrained, fluorinated amino acid analog for constructing peptide mimics to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis Catalyst Ligand: Potential utility as a precursor for chiral ligands or organocatalysts in enantioselective transformations.
• Biochemical Research: Used as a probe or standard in metabolic studies and enzyme-substrate interaction research due to its fluorinated structure.
• Fine Chemical Synthesis: An advanced intermediate for creating specialty chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	D-Proline, 4-Fluoro-5-Oxo-, (4R)- (9Ci)
CAS No.	160705-72-6
Molecular Formula	C5H6FNO3
Molecular Weight	147.10 g/mol
Synonyms	(4R)-4-Fluoro-5-oxo-D-proline; (4R)-4-Fluoropyroglutamic acid; 4-Fluoro-5-oxo-D-proline; 4-Fluoropyroglutamic acid, D-; 4-Fluoro-D-pyroglutamic acid; (R)-4-Fluoro-5-oxopyrrolidine-2-carboxylic acid; 160705-72-6; 4-Fluoro-DL-pyroglutamic acid (related)
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Fluoro-5-Oxo-, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications for identity, purity, and impurities are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.