Description

3-Amino-2,5,6-Trifluorobenzonitrile is a high-value fluorinated aromatic building block characterized by its unique combination of an amino group and a nitrile on a trifluorinated benzene ring. This structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the fluorine atoms enhance metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, where the fluorine content imparts desirable thermal and chemical resistance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Buchwald-Hartwig amination) and nucleophilic aromatic substitution to introduce complex fluorinated aniline derivatives.

Basic Information

Product Name	3-Amino-2,5,6-Trifluorobenzonitrile
CAS No.	159847-79-7
Molecular Formula	C7H2F3N2
Molecular Weight	174.10 g/mol
Synonyms	2,5,6-Trifluoro-3-aminobenzonitrile; 3-Amino-2,5,6-trifluorobenzene carbonitrile; 2,5,6-Trifluoro-3-cyanoaniline; Benzonitrile, 3-amino-2,5,6-trifluoro-; 3-Cyano-2,5,6-trifluoroaniline
EINECS	Contact for details

Quality Control

Our 3-Amino-2,5,6-Trifluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical and agrochemical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.