Description

Benzeneacetonitrile, 4-Fluoro-α-Methyl-, (S)- (9Ci) is a high-value chiral building block and key synthetic intermediate. This optically active compound is essential for the development of enantiomerically pure pharmaceuticals and advanced agrochemicals. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs targeting the central nervous system, anti-inflammatory agents, and other therapeutic molecules.
• Agrochemical Synthesis: Used in the research and production of advanced, enantiomerically pure pesticides and herbicides, where the specific (S)-configuration can be crucial for biological activity and environmental safety.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling more efficient and selective chemical transformations.
• Fine Chemical and Flavor/Fragrance Intermediate: Employed in the synthesis of complex, high-value specialty chemicals and as a building block for certain aroma chemicals.
• Academic and Industrial R&D: A valuable compound for methodological research in organic chemistry, particularly in studies involving fluorination, nitrile chemistry, and stereoselective synthesis.

Basic Information

Product Name	Benzeneacetonitrile, 4-Fluoro-α-Methyl-, (S)- (9Ci)
CAS No.	159517-51-8
Molecular Formula	C9H8FN
Molecular Weight	149.17 g/mol
Synonyms	(S)-4-Fluoro-α-methylbenzeneacetonitrile; (S)-2-(4-Fluorophenyl)propionitrile; (S)-α-Methyl-4-fluorobenzeneacetonitrile; (S)-4-Fluoro-2-phenylpropionitrile; (S)-1-(4-Fluorophenyl)ethyl cyanide; (S)-4-Fluoro-α-methylphenylacetonitrile; (S)-2-(p-Fluorophenyl)propionitrile; (S)-p-Fluoro-α-methylbenzyl cyanide
EINECS	Contact for details

Quality Control

Our production of Benzeneacetonitrile, 4-Fluoro-α-Methyl-, (S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for its applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We operate under a cGMP-compliant quality management system, and specifications can be tailored to meet the rigorous demands of pharmaceutical development (ICH Q7, USP guidelines) and other regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.