Description

Duocarmycin Tm is a potent synthetic analog of the duocarmycin family of antitumor antibiotics, characterized by its sequence-selective DNA alkylation properties. This compound is of significant interest for its role as a key pharmacophore and warhead in the development of novel antibody-drug conjugates (ADCs) and targeted cancer therapeutics. Researchers and pharmaceutical developers in oncology R&D require this high-purity building block to create next-generation bioconjugates and to study the mechanisms of DNA minor groove binding agents.

Application

• Critical payload (warhead) in the synthesis of novel Antibody-Drug Conjugates (ADCs) for targeted cancer therapy.
• Pharmacological reference standard for in vitro and in vivo studies investigating DNA alkylation and cytotoxicity.
• Core intermediate in medicinal chemistry research for designing and optimizing potent cytostatic agents.
• Tool compound for mechanistic studies of sequence-specific DNA recognition and damage.
• Building block for the development of prodrugs aimed at improving therapeutic windows.
• Active Pharmaceutical Ingredient (API) starting material for preclinical and clinical-stage pharmaceutical development.

Basic Information

Product Name	Duocarmycin Tm
CAS No.	157922-77-5
Molecular Formula	C31H34N4O7
Molecular Weight	574.62 g/mol
Synonyms	Duocarmycin TM; (1R,2R,8S,8aR)-1,2,8,8a-Tetrahydro-6-methoxy-1,2,8-trimethylpyrrolo[2,1-e]indol-4-yl (3S)-3-[[(2S)-1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinyl]carbonyl]oxy-5-methoxy-1H-indole-2-carboxylate; CC-1065 analog; ADC payload TM; DUO-TM; TM-Duocarmycin
EINECS	Contact for details

Quality Control

Every batch of Duocarmycin Tm is manufactured and analyzed under strict quality management systems to ensure identity, purity, and consistency suitable for advanced research and development. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.