Description

2-Bromo-4,4,4-trifluoro-2-butenenitrile is a versatile fluorinated building block characterized by its reactive bromine and nitrile functional groups. This compound is critical for introducing the trifluoromethyl moiety into complex molecular architectures, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the trifluoromethyl group improves biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric and optical properties.
• Polymer Modification: Employed to introduce fluorine atoms into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitutions to create complex, fluorinated organic molecules for research.
• Fluorinated Surfactant Precursor: Acts as an intermediate in the manufacture of specialty surfactants and surface treatment agents.

Basic Information

Product Name	2-Bromo-4,4,4-trifluoro-2-butenenitrile
CAS No.	157735-86-9
Molecular Formula	C4H1BrF3N
Molecular Weight	187.95 g/mol
Synonyms	2-Bromo-4,4,4-trifluorocrotononitrile; (Z)-2-Bromo-4,4,4-trifluorobut-2-enenitrile; 4,4,4-Trifluoro-2-bromo-2-butenenitrile; 2-Butenenitrile, 2-bromo-4,4,4-trifluoro-; Trifluoromethyl bromocrotononitrile; Bromotrifluorocrotononitrile; 157735-86-9
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,4,4-trifluoro-2-butenenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.