Description

tert-Butyl 4-Amino-3-Fluorobenzoate is a high-purity fluorinated benzoate derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing both amino and fluorinated aromatic functionalities into target molecules, enabling the development of compounds with enhanced biological activity and physicochemical properties. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atom can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic components in advanced electronic materials, contributing to improved performance in displays and lighting.
• Peptide Mimetics & Bio-conjugation: The amino and ester functional groups make it suitable for constructing peptide analogs or for use in linker chemistry for drug conjugates.
• Chemical Research & Process Development: Employed in academic and industrial laboratories for method development and scaling novel synthetic routes involving fluorinated anilines.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific, high-value intermediates under cGMP conditions where required.

Basic Information

Product Name	tert-Butyl 4-Amino-3-Fluorobenzoate
CAS No.	157665-53-7
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	4-Amino-3-fluorobenzoic acid tert-butyl ester; tert-Butyl 4-amino-3-fluorobenzoate; 3-Fluoro-4-aminobenzoic acid tert-butyl ester; Benzoic acid, 4-amino-3-fluoro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-amino-3-fluorobenzoate; t-Butyl 4-amino-3-fluorobenzoate; 4-(tert-Butoxycarbonyl)-2-fluoroaniline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-3-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.