Description

6-Chloro-2,3-Difluorobenzonitrile, 97% is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for introducing the unique electronic and steric properties of chlorine and fluorine substituents into complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoro-chloro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Buchwald-Hartwig amination to construct complex biaryl systems.
• Nitrile Transformation Chemistry: The cyano group can be readily converted into carboxylic acids, amides, tetrazoles, and other valuable functional groups.
• Material Science Research: Employed in the synthesis of novel polymers and ligands with tailored electronic properties for catalytic and sensing applications.

Basic Information

Product Name	6-Chloro-2,3-Difluorobenzonitrile, 97%
CAS No.	157647-02-4
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2,3-Difluoro-6-chlorobenzonitrile; 6-Chloro-2,3-difluorobenzonitrile; 2-Chloro-5,6-difluorobenzonitrile; Benzonitrile, 6-chloro-2,3-difluoro-; 1-Chloro-3,4-difluoro-2-cyanobenzene; 3,4-Difluoro-2-chlorobenzonitrile; 157647-02-4 (CAS); 6-Chloro-2,3-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,3-Difluorobenzonitrile is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure the specified purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.