Description

2-Amino-5-Bromo-3-Nitrobenzotrifluoride is a high-value, multi-functional aromatic intermediate featuring a trifluoromethyl group, a bromo substituent, and both amino and nitro functional groups. This unique combination of reactive sites makes it a critical building block for the synthesis of complex, fine chemicals and active pharmaceutical ingredients (APIs). It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical sectors for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast azo dyes and complex organic pigments.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries in drug discovery programs.

Basic Information

Item	Details
Product Name	2-Amino-5-Bromo-3-Nitrobenzotrifluoride
CAS No.	157026-18-1
Molecular Formula	C7H4BrF3N2O2
Molecular Weight	285.02 g/mol
Synonyms	2-Amino-5-bromo-3-nitro-α,α,α-trifluorotoluene; 5-Bromo-2-amino-3-nitrobenzotrifluoride; 2-Amino-5-bromo-3-nitrobenzotrifluoride; 1-Amino-4-bromo-2-nitro-5-(trifluoromethyl)benzene; 4-Bromo-2-nitro-5-(trifluoromethyl)aniline; 5-Bromo-2-nitro-α,α,α-trifluoro-m-toluidine; Benzene, 1-amino-4-bromo-2-nitro-5-(trifluoromethyl)-; ANBTF
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Bromo-3-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.