Description

1H-Pyrrolizine-1,2,7-Triol, 3-(Fluoromethyl)Hexahydro-, Triacetate (Ester), 1R-(1.Alpha.,2.Beta.,3.Alpha.,7.Beta.,7A.Alpha.)- is a high-purity, fluorinated pyrrolizine derivative with a defined stereochemistry, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a complex, multi-functional chiral scaffold essential for constructing sophisticated target molecules, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced, fluorinated active ingredients with enhanced biological activity and environmental profile.
• Chemical Biology Probe Development: Serves as a core structure for creating tool compounds to study enzyme mechanisms and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Potential starting material for the synthesis of novel chiral ligands and organocatalysts.
• Natural Product Analog Synthesis: Enables the semi-synthesis and structural modification of complex natural products containing pyrrolizidine alkaloid motifs.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in fluorination and stereoselective synthesis.

Basic Information

Product Name	1H-Pyrrolizine-1,2,7-Triol, 3-(Fluoromethyl)Hexahydro-, Triacetate (Ester), 1R-(1.Alpha.,2.Beta.,3.Alpha.,7.Beta.,7A.Alpha.)-
CAS No.	156205-46-8
Molecular Formula	C15H21FNO6
Molecular Weight	330.33 g/mol
Synonyms	(1R,2R,3R,7S,7aR)-3-(Fluoromethyl)hexahydro-1H-pyrrolizine-1,2,7-triyl triacetate; 3-(Fluoromethyl)hexahydro-1H-pyrrolizine-1,2,7-triol triacetate (1R,2R,3R,7S,7aR)-; 1R-(1α,2β,3α,7β,7aα)-3-(Fluoromethyl)hexahydro-1H-pyrrolizine-1,2,7-triyl triacetate; Fluoromethyl pyrrolizine triacetate; CAS 156205-46-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.