Description

Tilisolol Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with the CAS registry number 155346-81-9. This compound is valued for its critical role in the synthesis and development of β-adrenergic blocking agents, which are essential in cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers engaged in the production of advanced drug substances.

Application

• Pharmaceutical API Synthesis: Primary use as a key intermediate in the manufacture of Tilisolol and related β-blocker active pharmaceutical ingredients.
• Cardiovascular Drug Research: Serves as a critical reference standard and building block in preclinical and clinical research for hypertension and angina treatments.
• Process Development: Utilized in scaling up and optimizing synthetic routes for β-adrenergic antagonists in pilot plants and commercial production.
• Analytical Standard: Employed as a certified reference material (CRM) for quality control, method validation, and regulatory compliance testing (e.g., HPLC, NMR).
• Fine Chemical Intermediate: Used in custom synthesis and contract manufacturing for specialized pharmaceutical and life science applications.

Basic Information

Product Name	Tilisolol Hydrochloride
CAS No.	155346-81-9
Molecular Formula	C17H28N2O3S • HCl
Molecular Weight	392.95 g/mol
Synonyms	1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol Hydrochloride; Tilisolol HCl; (±)-Tilisolol Hydrochloride; 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1,2,5-thiadiazol-3-yl]morpholine Hydrochloride; BRN 9228286; UNII-4T6K7T8Q3Q
EINECS	Contact for details

Quality Control

Our Tilisolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.