Description

Anhydro Abiraterone is a high-purity pharmaceutical intermediate and reference standard of significant importance in modern therapeutic development. This compound is a key derivative in the synthesis and analytical profiling of Abiraterone Acetate, a critical active pharmaceutical ingredient (API) used in oncology. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in the development, quality control, and production of advanced prostate cancer treatments.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of Abiraterone Acetate API.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, GC, LC-MS) of final drug substances and products.
• Process Research & Development (R&D): Employed in route scouting, impurity profiling, and the development of robust manufacturing processes.
• Metabolite Studies: Serves as a relevant compound for in-vitro and in-vivo metabolic and pharmacokinetic research related to Abiraterone.
• Regulatory Submissions: Provides essential chemical reference material for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).
• Academic Research: Used in biochemical and pharmacological studies to investigate steroidogenesis pathways and related therapeutic targets.

Basic Information

Product Name	Anhydro Abiraterone
CAS No.	154229-20-6
Molecular Formula	C24H29NO
Molecular Weight	347.50 g/mol
Synonyms	(3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-16-one; 17-(3-Pyridyl)androsta-5,16-dien-3β-ol; Abiraterone Impurity; Abiraterone Related Compound A; Dehydroabiraterone
EINECS	Contact for details

Quality Control

Our Anhydro Abiraterone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory requirements for cGMP, ICH guidelines, and pharmacopeial standards (USP/EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.