Description

Abiraterone CAS NO 154229-19-3 is a potent and selective inhibitor of the enzyme CYP17A1 (17α-hydroxylase/17,20-lyase). This compound is a critical active pharmaceutical ingredient (API) in the treatment of metastatic castration-resistant prostate cancer (mCRPC). It is essential for pharmaceutical manufacturers and research institutions developing advanced oncology therapeutics. The high-purity material is vital for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for prostate cancer therapy.
• Oncology Drug Development: Key intermediate or reference standard in the R&D of novel anti-cancer drugs targeting hormone-sensitive pathways.
• Biochemical Research: Used as a specific tool compound in studies investigating steroidogenesis, androgen biosynthesis, and CYP450 enzyme function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Formulation Development: Utilized in the development of various dosage forms, including tablets and other oral formulations.

Basic Information

Product Name	Abiraterone
CAS No.	154229-19-3
Molecular Formula	C24H31NO
Molecular Weight	349.51 g/mol
Synonyms	Abiraterone Acetate (prodrug form); CB-7598; (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol; 17-(3-Pyridyl)androsta-5,16-dien-3β-ol; Zytiga® (brand name API)
EINECS	Contact for details

Quality Control

Our Abiraterone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing results from tests such as HPLC, NMR, and MS. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards (USP/EP) for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.