Description

Cephalostatin 10 is a highly potent, naturally occurring bis-steroidal pyrazine marine alkaloid isolated from the marine worm *Cephalodiscus gilchristi*. This compound is of significant interest due to its exceptional and selective cytotoxicity against various cancer cell lines, particularly P-388 murine leukemia cells, at picomolar concentrations. It is a critical reference standard and research chemical for pharmaceutical R&D, specifically in oncology, apoptosis studies, and the development of novel anti-cancer therapeutics. Researchers and developers in the fields of medicinal chemistry, pharmacology, and preclinical drug discovery require this high-purity compound for advanced biological screening and mechanism-of-action studies.

Application

• Oncology Research: As a potent cytotoxic agent for in vitro and in vivo studies targeting leukemia and other cancer cell lines.
• Apoptosis Induction Studies: Used to investigate programmed cell death pathways and mechanisms in cancer biology.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug discovery pipelines.
• Medicinal Chemistry: A key structural template for the design, synthesis, and structure-activity relationship (SAR) studies of novel anti-cancer agents.
• Biochemical Research: Tool compound for studying mitochondrial function, caspase activation, and other intracellular signaling pathways affected by bis-steroidal alkaloids.
• Preclinical Drug Development: Evaluation of efficacy, pharmacokinetics, and toxicology in animal models for potential therapeutic candidates.

Basic Information

Product Name	Cephalostatin 10
CAS No.	153698-87-4
Molecular Formula	C₅₄H₇₄N₂O₁₀
Molecular Weight	911.18 g/mol
Synonyms	13-Deoxy-17-dehydroxyl-cephalostatin 1; 13-Deoxy-17-dehydrocephalostatin 1; Cephalostatin-10; NSC-106572; 1H-Pyrazine, 2,3-dihydro-3,3'-[(1S,2S,3aS,3a'S,5aS,5a'S,5bS,5b'S,9aS,9a'S,10R,10'R,11aS,11a'S,12S,12'S)-dodecahydro-1,1',2,2',10,10',11a,11a'-octahydroxy-5b,5b',9a,9a'-tetramethyl-7,7'-bi(cyclopenta[a]phenanthren)-3,3'-diyl]bis[5,6,7,8-tetrahydro-2-methyl-]; (1S,2S,3aS,3a'S,5aS,5a'S,5bS,5b'S,9aS,9a'S,10R,10'R,11aS,11a'S,12S,12'S)-3,3'-[Dodecahydro-1,1',2,2',10,10',11a,11a'-octahydroxy-5b,5b',9a,9a'-tetramethyl-7,7'-bi(cyclopenta[a]phenanthren)-3,3'-diyl]bis[5,6,7,8-tetrahydro-2-methyl-2,3-dihydro-1H-pyrazine]
EINECS	Contact for details

Quality Control

Our Cephalostatin 10 is produced and handled under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, essential for sensitive biological research. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support compliance with research and development standards, and custom purity grades or analytical services are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and must be stored under inert atmosphere (argon or nitrogen) in sealed vials to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.