Description

(R)-Azelastine Hydrochloride CAS NO 153408-28-7 is the single enantiomer of the potent, second-generation H1-antihistamine and mast cell stabilizer. This high-purity chiral intermediate is critical for the development of advanced pharmaceutical formulations with enhanced specificity and reduced side-effect profiles. It is primarily required by pharmaceutical R&D departments and manufacturers specializing in novel ophthalmic solutions, nasal sprays, and other targeted allergy and anti-inflammatory therapeutics.

Application

• Active Pharmaceutical Ingredient (API) for enantiomerically pure antihistamine medications.
• Key chiral intermediate in the synthesis of advanced ophthalmic solutions for allergic conjunctivitis.
• Critical starting material for nasal spray formulations targeting allergic rhinitis.
• Research and development of new mast cell stabilizers with improved receptor selectivity.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Building block for novel chemical entities in immunology and inflammation research.

Basic Information

Product Name	(R)-Azelastine Hydrochloride
CAS No.	153408-28-7
Molecular Formula	C22H24ClN3O • HCl
Molecular Weight	418.36 g/mol (as hydrochloride salt)
Synonyms	(R)-Azelastine HCl; (R)-4-[(4-Chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one Hydrochloride; (R)-Azelastine Hydrochloride; (R)-(-)-Azelastine Hydrochloride; Azelastine (R)-Enantiomer Hydrochloride; (R)-Azelastine Monohydrochloride; (R)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-, monohydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Azelastine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity by HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.