Description

(S)-Azelastine Hydrochloride CAS NO 153408-27-6 is the single enantiomer form of the potent, second-generation H1-receptor antagonist, azelastine hydrochloride. This high-purity chiral intermediate is critical for pharmaceutical development, offering superior specificity and reduced side-effect profiles compared to racemic mixtures. It is essential for manufacturers in the pharmaceutical industry focused on developing advanced ophthalmic and intranasal antihistamine formulations, as well as for research institutions conducting pharmacological studies.

Application

• Active Pharmaceutical Ingredient (API) for ophthalmic solutions targeting allergic conjunctivitis.
• Key chiral building block in the synthesis of modern intranasal antihistamine and mast cell stabilizer sprays.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Pharmacological research material for studying enantiomer-specific H1-receptor binding and activity.
• Process development for the commercial-scale manufacturing of enantiomerically pure azelastine-based therapeutics.
• Formulation development of novel drug delivery systems leveraging the (S)-enantiomer's efficacy.

Basic Information

Product Name	(S)-Azelastine Hydrochloride
CAS No.	153408-27-6
Molecular Formula	C22H24ClN3O • HCl
Molecular Weight	418.36 g/mol (as hydrochloride salt)
Synonyms	(S)-Azelastine HCl; (-)-Azelastine Hydrochloride; (4-[(4R,6S)-6-[(S)-(4-Chlorophenyl)(phenyl)methyl]-1-methyl-2-piperazinyl]-1(2H)-phthalazinone Monohydrochloride; (S)-(-)-4-[(4-Chlorophenyl)-2-pyridinylmethyl]-1-methylpiperazine Hydrochloride; Optivar (Enantiomer); Astepro (Enantiomer); Allergodil (Enantiomer); CAS 153408-27-6
EINECS	Contact for details

Quality Control

Our (S)-Azelastine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure compliance with high-purity standards suitable for pharmaceutical development and research. Comprehensive testing includes chiral purity, chemical purity, and identification. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.