Description

Bevantolol Hydrochloride is a selective β-1 adrenergic receptor antagonist (β-blocker) in its hydrochloride salt form, offering enhanced stability and solubility for pharmaceutical development. This compound is critical for research into cardiovascular therapeutics, particularly for managing hypertension and angina. It serves as a key active pharmaceutical ingredient (API) and reference standard for pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in drug discovery and quality control.

Application

• Pharmaceutical API Intermediate: Serves as a critical building block in the synthesis of finished dosage forms of bevantolol.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of pharmaceutical products.
• Biochemical Research: Employed in pharmacological studies to investigate β-1 adrenergic receptor mechanisms and cardiac function.
• Preclinical Development: Utilized in formulation studies and stability testing for new cardiovascular drug candidates.
• Impurity Profiling: Acts as a primary standard to identify and quantify related substances in drug substance batches.

Basic Information

Product Name	Bevantolol Hydrochloride
CAS No.	152510-37-7
Molecular Formula	C20H27NO4 • HCl
Molecular Weight	381.89 g/mol
Synonyms	1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride; Bevantolol HCl; (±)-Bevantolol Hydrochloride; DL-Bevantolol Hydrochloride; N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-[3-(m-tolyloxy)-2-hydroxypropyl]ethylenediamine Hydrochloride; C-2241; ICI 204,636
EINECS	Contact for details

Quality Control

Our Bevantolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.