Description

Acolbifene is a selective estrogen receptor modulator (SERM) with a well-defined chemical structure. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and endocrinology.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical and clinical studies for hormone-related therapies.
• Oncology Research: Investigated for its potential application in the treatment and management of estrogen receptor-positive (ER+) cancers, including certain breast cancers.
• Biochemical Research: Used as a reference standard or probe compound in studies of estrogen receptor signaling pathways and SERM pharmacology.
• Academic Research: Employed in university and institutional laboratories for fundamental studies in medicinal chemistry and molecular biology.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the synthesis of more complex drug candidates or for scale-up processes.

Basic Information

Product Name	Acolbifene
CAS No.	151533-34-5
Molecular Formula	C30H37NO4
Molecular Weight	475.62 g/mol
Synonyms	EM-652; SCH 57068; Acoblofen; (S)-4-(7-(2,2-Dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-3-yl)phenyl 2,2-dimethylpropanoate; TSE-424; (S)-TSE-424; EM-652.HCl; Acolbifene Hydrochloride
EINECS	Contact for details

Quality Control

Our Acolbifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.