Description

Cyclopentaneacetic Acid, -α--Fluoro-1-Hydroxy-, Ethyl Ester (9Ci) is a specialized fluorinated organic ester building block of significant interest in advanced synthetic chemistry. This compound matters for its unique structural features, combining a cyclopentane ring with fluorine and hydroxyl substituents, which are critical for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and pesticides where the fluorinated cyclopentane structure contributes to efficacy and environmental profile.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, or organic electronic materials requiring specific steric and electronic properties.
• Asymmetric Synthesis: Employed in stereoselective reactions due to its chiral center, useful for constructing complex natural products and fine chemicals.
• Biochemical Research: Utilized as a probe or labeled compound in metabolic pathway studies and medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients requiring bespoke fluorinated compounds.

Basic Information

Product Name	Cyclopentaneacetic Acid, -α--Fluoro-1-Hydroxy-, Ethyl Ester (9Ci)
CAS No.	151395-78-7
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	Ethyl 2-Fluoro-2-hydroxy-2-cyclopentylacetate; 2-Cyclopentyl-2-fluoro-2-hydroxyacetic Acid Ethyl Ester; α-Fluoro-α-hydroxycyclopentaneacetic Acid Ethyl Ester; 2-Fluoro-2-hydroxy-2-cyclopentylethanoic Acid Ethyl Ester; Ethyl α-Fluoro-α-hydroxycyclopentylacetate; (RS)-Ethyl 2-cyclopentyl-2-fluoro-2-hydroxyacetate; 151395-78-7; 9CI
EINECS	Contact for details

Quality Control

Our Cyclopentaneacetic Acid, -α--Fluoro-1-Hydroxy-, Ethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.