Description

(16α)-21-Chloro-17-Hydroxy-16-Methylpregna-1,4,9(11)-Triene-3,20-Dione is a high-purity synthetic steroid derivative with a complex, modified pregnane structure. This compound is a critical pharmaceutical intermediate for the research and development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in advanced steroid synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel corticosteroid analogs and other biologically active steroid molecules.
• Research & Development: Used in academic and industrial research to study structure-activity relationships (SAR) of modified steroids.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Studies: Employed in the development and testing of new drug candidates targeting hormonal pathways or inflammatory responses.
• Process Chemistry: Used in scaling up synthetic routes for the production of advanced steroid-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(16α)-21-Chloro-17-Hydroxy-16-Methylpregna-1,4,9(11)-Triene-3,20-Dione
CAS No.	151265-36-0
Molecular Formula	C22H25ClO3
Molecular Weight	372.89 g/mol
Synonyms	21-Chloro-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione-17α-ol; 16α-Methyl-21-chloro-1,4,9(11)-pregnatriene-3,20-dione-17α-ol; 21-Chloro-16α-methylpregna-1,4,9(11)-triene-3,20-dione-17α-ol; (16α)-21-Chloro-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; 16α-Methyl-21-chloro-δ1,4,9(11)-pregnatriene-3,20-dione-17α-ol
EINECS	Contact for details

Quality Control

Our (16α)-21-Chloro-17-Hydroxy-16-Methylpregna-1,4,9(11)-Triene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.