Description

(9B,11B,16A)-9,11-Epoxy-21-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione CAS NO 151265-33-7 is a high-purity synthetic steroid derivative characterized by its unique epoxy and diene functional groups. This compound serves as a critical pharmaceutical intermediate in the synthesis of advanced corticosteroid and anti-inflammatory APIs, where its precise stereochemistry is essential for biological activity. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent glucocorticoid receptor agonists and related steroid-based drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research for creating new corticosteroid molecules with targeted anti-inflammatory and immunosuppressive properties.
• Biochemical Research: Serves as a reference standard and a tool compound in steroid hormone receptor binding studies and metabolic pathway research.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex steroid architectures in pilot plants and commercial manufacturing.

Basic Information

Product Name	(9B,11B,16A)-9,11-Epoxy-21-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	151265-33-7
Molecular Formula	C22H28O5
Molecular Weight	372.46 g/mol
Synonyms	9β,11β-Epoxy-21-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; 16α-Methyl-9β,11β-epoxypregna-1,4-diene-3,20-dione-21-ol; 9β,11β-Epoxy-16α-methyl-1,4-pregnadiene-3,20-dione-21-ol; (9β,11β,16α)-9,11-Epoxy-21-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 16α-Methyl-9β,11β-oxidopregna-1,4-diene-3,20-dione-21-ol; A key steroid synthon for corticosteroid synthesis.
EINECS	Contact for details

Quality Control

Our (9B,11B,16A)-9,11-Epoxy-21-Hydroxy-16-Methylpregna-1,4-Diene-3,20-Dione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific pharmaceutical grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.