Description

3-Fluoro-5-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing both fluorine and trifluoromethyl substituents into complex molecular architectures. Its unique electronic and steric properties make it a critical intermediate in the development of advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and industrial manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors for synthesizing novel compounds with enhanced biological activity and material performance.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in the development of kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and trifluoromethyl groups improve metabolic stability and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), enhancing charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific properties such as chemical resistance, low surface energy, and improved weatherability.
• Organic Synthesis Reagent: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution, enabling complex molecule construction in medicinal chemistry.
• Fluorinated Dye & Pigment Precursor: Used in the synthesis of specialty dyes and pigments with unique color fastness and optical properties.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Benzonitrile
CAS No.	149793-69-1
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	3-Fluoro-5-(trifluoromethyl)benzonitrile; 5-Cyano-1-fluoro-3-(trifluoromethyl)benzene; 1-Fluoro-3-cyano-5-(trifluoromethyl)benzene; 3-Fluoro-α,α,α-trifluoro-m-toluonitrile; m-(Trifluoromethyl)-5-fluorobenzonitrile; 3-Fluoro-5-trifluoromethylbenzonitrile; 5-Fluoro-3-(trifluoromethyl)benzonitrile; Benzene, 1-cyano-3-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment. We support cGMP and ISO 9001 compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.