Description

Jadomycin B CAS NO 149633-99-8 is a naturally occurring angucycline antibiotic and secondary metabolite produced by certain strains of *Streptomyces venezuelae*. This compound is of significant interest in chemical biology and pharmaceutical research due to its potent biological activity and unique molecular scaffold. It serves as a valuable reference standard and a promising lead compound for researchers in drug discovery, microbiology, and synthetic chemistry.

Application

• Pharmaceutical Research & Development: As a reference standard for analytical method development, quality control, and biological activity studies.
• Antibiotic Mechanism Studies: Investigation of its mode of action against Gram-positive bacteria and its potential to overcome antibiotic resistance.
• Chemical Biology Probes: Utilization of its unique structure to study DNA interaction, topoisomerase inhibition, and cellular pathways.
• Lead Compound Optimization: Serving as a core scaffold for the semi-synthesis of novel analogs with improved pharmacological properties.
• Academic & Institutional Research: Fundamental studies in natural product chemistry, biosynthesis, and microbial genetics.
• Biochemical Assay Development: Used as a known active agent in high-throughput screening (HTS) campaigns for new antimicrobials.

Basic Information

Product Name	Jadomycin B
CAS No.	149633-99-8
Molecular Formula	C30H27NO9
Molecular Weight	545.54 g/mol
Synonyms	Jadomycin B; Antibiotic U-58,431; U-58431; 5H-Benzol[a]carbazol-6-one, 1,2,3,4,4a,12b-hexah-10,11-dihydroxy-8-methoxy-1,4a-dimethyl-7-(1-methylethenyl)-, (4aS,12bR)-; Jadomycin-B; (4aS,12bR)-10,11-Dihydroxy-8-methoxy-1,4a-dimethyl-7-(prop-1-en-2-yl)-1,2,3,4,4a,12b-hexahydro-5H-benzo[a]carbazol-6-one
EINECS	Contact for details

Quality Control

Our Jadomycin B is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Red to orange-red solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.