Description

α-D-Ribofuranosylamine,2-Deoxy-2-Fluoro-(9Ci) is a fluorinated nucleoside derivative, a key building block in medicinal chemistry and biochemical research. Its modified sugar moiety, featuring a fluorine atom at the 2' position, is crucial for imparting metabolic stability and altering binding affinity in nucleotide analogs. This high-purity intermediate is essential for researchers and manufacturers developing novel antiviral agents, anticancer therapeutics, and molecular probes. The compound, CAS 149624-21-5, is supplied under stringent quality control to ensure reliability for sensitive pharmaceutical synthesis and advanced life science applications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of fluorinated nucleoside analogs used in antiviral and anticancer drug discovery.
• Antiviral Drug Development: Serves as a precursor for modified nucleotides targeting viral polymerases in diseases such as hepatitis and influenza.
• Oncology Research: Used in creating chemotherapeutic agents that incorporate fluorinated sugars to enhance cellular uptake and efficacy.
• Biochemical Probes: Employed in the synthesis of labeled nucleotides for studying enzyme mechanisms and nucleic acid interactions.
• PET Tracer Synthesis: Potential precursor for developing positron emission tomography (PET) imaging agents containing fluorine-18.
• Glycobiology Studies: Useful for investigating the role of fluorinated carbohydrates in biological recognition processes.

Basic Information

Item	Details
Product Name	α-D-Ribofuranosylamine,2-Deoxy-2-Fluoro-(9Ci)
CAS No.	149624-21-5
Molecular Formula	C5H11FN2O4
Molecular Weight	182.15 g/mol
Synonyms	2-Deoxy-2-fluoro-D-ribofuranosylamine; 2-Fluoro-2-deoxy-D-ribofuranosylamine; 2'-Deoxy-2'-fluororibofuranosylamine; 2-Fluoro-2-deoxy-α-D-ribofuranosylamine; 2-Fluoro-2-deoxy-D-ribosylamine; 2'-Fluoro-2'-deoxyribofuranosylamine; α-2-Fluoro-2-deoxyribofuranosylamine; 149624-21-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our α-D-Ribofuranosylamine,2-Deoxy-2-Fluoro-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and MS. We support regulatory documentation needs for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.