Description

2,4-Difluoro-3-Formylbenzonitrile is a high-value, multi-functional aromatic building block characterized by its reactive aldehyde and nitrile groups flanked by fluorine substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique substitution pattern enables precise structural modifications. It is primarily needed by R&D chemists and process development scientists working on advanced active ingredients, including kinase inhibitors, herbicides, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research and production of advanced polymers and liquid crystals with specific electronic or optical properties.
• Chemical Research: A versatile reagent for heterocyclic chemistry, enabling the construction of fluorinated pyridines, quinolines, and other nitrogen-containing rings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	2,4-Difluoro-3-Formylbenzonitrile
CAS No.	149489-14-5
Molecular Formula	C8H3F2NO
Molecular Weight	167.11 g/mol
Synonyms	3-Cyano-2,4-difluorobenzaldehyde; 2,4-Difluorobenzaldehyde-3-carbonitrile; 2,4-Difluoro-3-formylbenzonitrile; 3-Formyl-2,4-difluorobenzonitrile; Benzaldehyde, 3-cyano-2,4-difluoro-; 149489-14-5; 2,4-Difluoro-3-aldehydobenzonitrile
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Formylbenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material that meets stringent internal specifications and can provide guidance on relevant pharmacopeial standards (e.g., ICH guidelines) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.