Description

D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4S)-Rel- (9Ci) is a high-purity, fluorinated derivative of glutamic acid, specifically designed as a sophisticated chiral building block for advanced organic synthesis. This compound matters for its role in introducing fluorine atoms and specific stereochemistry into target molecules, a critical strategy in modern medicinal chemistry for modulating pharmacokinetic properties. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including potential enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in oncology and CNS disorders.
• Peptidomimetics Research: Used to incorporate fluorinated glutamic acid analogs into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Protease & Enzyme Inhibitor Design: Serves as a core scaffold for creating inhibitors that target specific enzymes, leveraging the fluorine atom for binding affinity.
• Agrochemical Synthesis: Employed in the development of advanced, fluorinated herbicides and pesticides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological mechanisms and pathways.
• Asymmetric Synthesis: Acts as a starting material or intermediate in complex multi-step asymmetric syntheses requiring high enantiomeric purity.

Basic Information

Product Name	D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4S)-Rel- (9Ci)
CAS No.	148267-91-8
Molecular Formula	C7H13FNO4 · HCl
Molecular Weight	237.64 g/mol (Free base: 193.18 g/mol)
Synonyms	(2S)-2-Amino-4-fluoro-4-oxobutanoic acid dimethyl ester hydrochloride; Dimethyl (2S)-2-amino-4-fluoro-4-oxobutanoate hydrochloride; (4S)-rel-4-Fluoro-D-glutamic Acid Dimethyl Ester Hydrochloride; 4-Fluoro-DL-glutamic Acid Dimethyl Ester Hydrochloride (rel); Fluoroglutamic Acid Dimethyl Ester Hydrochloride; D-4-Fluoroglutamic Acid Dimethyl Ester HCl; (S)-2-Azaniumyl-4-fluoro-4-oxobutanoate dimethyl ester chloride
EINECS	Contact for details

Quality Control

Our D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4S)-Rel- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric purity, and impurity profiles. We adhere to relevant industry standards for fine chemical synthesis, and specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.