Description

(+)-Mequitazine CAS NO 147780-50-5 is the enantiomerically pure form of Mequitazine, a potent and selective histamine H1 receptor antagonist. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of advanced antihistamine agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing enantioselective drugs for allergy and respiratory conditions.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure antihistamine pharmaceuticals.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Building block for research into novel histamine H1 receptor antagonists with improved selectivity.
• Precursor for pharmacological studies investigating the stereospecific effects of mequitazine.
• Used in process chemistry development for the scale-up of single-enantiomer drug production.
• Critical material for academic and industrial research in medicinal chemistry and allergy therapeutics.

Basic Information

Product Name	(+)-Mequitazine
CAS No.	147780-50-5
Molecular Formula	C20H22N2S
Molecular Weight	322.47 g/mol
Synonyms	(+)-Mequitazine; (R)-Mequitazine; Dexmequitazine; Mequitazine enantiomer; LM 209; LM-209; 10-[(1R)-1-Methyl-3-pyrrolidinyl]methyl-10H-phenothiazine; (R)-10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
EINECS	Contact for details

Quality Control

Our (+)-Mequitazine is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and identity confirmation. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.