Description

(-)-Hydroxyzine CAS NO 147152-23-6 is the specific enantiomer of the well-known antihistamine and anxiolytic agent, Hydroxyzine. This compound is of significant interest for pharmaceutical research and development, particularly in the study of stereoselective pharmacology and the development of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in advanced drug discovery and formulation.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of enantiomerically pure pharmaceutical compounds.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Pharmacological Research: Essential for preclinical studies investigating the distinct biological activity, metabolism, and toxicity profile of the (-)-enantiomer.
• Process Chemistry Development: Employed in the development and optimization of asymmetric synthesis routes within API manufacturing.
• Impurity Profiling: Acts as a critical marker for monitoring stereochemical purity and identifying enantiomeric impurities in bulk drug substances.

Basic Information

Product Name	(-)-Hydroxyzine
CAS No.	147152-23-6
Molecular Formula	C21H27ClN2O2
Molecular Weight	374.91 g/mol
Synonyms	(-)-Hydroxyzine; (2R)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]ethanol; Levohydroxyzine; (R)-Hydroxyzine; Atarax (enantiomer); Vistaril (enantiomer); Hydroxyzine L-isomer; Hydroxyzine (-)-form
EINECS	Contact for details

Quality Control

Our (-)-Hydroxyzine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.