Description

(+)-Hydroxyzine CAS NO 147152-22-5 is the dextrorotatory enantiomer of hydroxyzine, a piperazine derivative with significant pharmacological activity. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in stereoselective synthesis and the development of novel antihistaminic or anxiolytic compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Research & Development: Used in pharmacological studies to investigate the specific biological activity and metabolic pathways of the (+)-enantiomer.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in the development and optimization of asymmetric synthesis routes for scale-up production.
• Academic Research: Utilized in university and institutional labs for studies in medicinal chemistry, stereochemistry, and drug discovery.

Basic Information

Product Name	(+)-Hydroxyzine
CAS No.	147152-22-5
Molecular Formula	C21H27ClN2O2
Molecular Weight	374.91 g/mol
Synonyms	(+)-Hydroxyzine; (R)-Hydroxyzine; Dextro-Hydroxyzine; (2R)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]ethanol; Levorex; CAS 147152-22-5
EINECS	Contact for details

Quality Control

Our (+)-Hydroxyzine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.