Description

Alcaftadine is a selective histamine H1 receptor antagonist with potent anti-allergic properties. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing ocular allergic responses. It is primarily required by pharmaceutical manufacturers and research institutions developing advanced ophthalmic solutions. The material is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical industry.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription ophthalmic solutions for the treatment of allergic conjunctivitis.
• Key component in clinical research and development of novel anti-allergy medications.
• Reference standard for analytical method development and quality control testing in pharmaceutical laboratories.
• Intermediate for the synthesis of more complex therapeutic agents targeting histamine pathways.
• Used in preclinical studies to investigate mechanisms of allergic inflammation and mast cell stabilization.

Basic Information

Product Name	Alcaftadine
CAS No.	147084-10-4
Molecular Formula	C19H21N3O
Molecular Weight	307.39 g/mol
Synonyms	11-(3-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-amine; 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-amine; R 89674; Alcaftadine free base
EINECS	Contact for details

Quality Control

Our Alcaftadine is manufactured and tested to meet high-purity pharmaceutical standards. Quality assurance includes rigorous analytical testing for identity, purity, and impurity profiles in compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from tests such as HPLC assay, related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.