Description

5,5,5-Trifluoro-4-Hydroxy-4-Phenyl-Pentan-2-One is a high-value fluorinated β-hydroxy ketone building block, essential for introducing trifluoromethyl and phenyl functionalities into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and specialty agrochemicals. This compound is primarily sought by research institutions and industrial manufacturers in the life sciences and fine chemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its impact on molecular polarity and stability.
• Asymmetric Catalysis Research: Employed as a chiral building block or ligand precursor in academic and industrial research for developing new catalytic methodologies.
• Polymer Modification: Functional monomer for creating specialty polymers with enhanced chemical resistance and tailored surface properties.
• Fluorine Chemistry Research: A valuable standard and starting material for exploring new reactions and properties of organofluorine compounds.

Basic Information

Product Name	5,5,5-Trifluoro-4-Hydroxy-4-Phenyl-Pentan-2-One
CAS No.	146801-29-8
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	4-Hydroxy-4-phenyl-5,5,5-trifluoropentan-2-one; 5,5,5-Trifluoro-4-hydroxy-4-phenylpentan-2-one; 1,1,1-Trifluoro-4-hydroxy-4-phenylpentan-2-one; 4-Phenyl-5,5,5-trifluoro-4-hydroxypentan-2-one; α-(Trifluoromethyl)-β-hydroxy-β-phenylpropiophenone; TFHPP; Trifluoromethyl β-hydroxy ketone derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, providing full transparency and traceability for your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.