Description

5-Chloro-2,4-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated components in electronic display technologies and organic light-emitting diodes.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or low surface energy properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the benzonitrile core into more complex molecular architectures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	5-Chloro-2,4-Difluorobenzonitrile
CAS No.	146780-26-9
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2,4-Difluoro-5-chlorobenzonitrile; 5-Chloro-2,4-difluorobenzene carbonitrile; 5-Chloro-2,4-difluorophenyl cyanide; Benzonitrile, 5-chloro-2,4-difluoro-; 146780-26-9; 5-Chloro-2,4-difluorobenzonitrile; 2,4-Difluoro-5-chlorobenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global clientele in fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee supply reliability and product traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.