Description

5-Bromo-2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b]thiophene is a high-purity, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique structure, which incorporates both bromine and fluorine substituents on a dihydrobenzo[b]thiophene scaffold, enabling precise molecular modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a precursor for novel pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Used in the synthesis of specialty polymers and liquid crystals, where the benzo[b]thiophene core contributes to desired electronic and optical properties.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport materials or host molecules in OLED device fabrication.
• Cross-Coupling Reactions: The bromine atom provides a handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex molecular architectures.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of polyfluorination on the reactivity and physical properties of heterocyclic systems.

Basic Information

Product Name	5-Bromo-2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b]thiophene
CAS No.	146431-20-1
Molecular Formula	C8H3BrF4S
Molecular Weight	287.07 g/mol
Synonyms	5-Bromo-2,2,3,3-tetrafluoro-2,3-dihydro-1-benzothiophene; 2,3-Dihydro-5-bromo-2,2,3,3-tetrafluorobenzo[b]thiophene; Benzo[b]thiophene, 5-bromo-2,2,3,3-tetrafluoro-2,3-dihydro-; 146431-20-1; 5-Bromo-2,2,3,3-tetrafluorodihydrobenzo[b]thiophene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b]thiophene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.