Description

2-Fluoro-4-(trifluoromethyl)benzonitrile is a high-value fluorinated aromatic nitrile building block. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates in drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the construction of electron-deficient units for organic semiconductors and non-fullerene acceptors in organic photovoltaics (OPVs).
• Cross-Coupling Reactions: The nitrile and halogen groups make it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Research: An important standard and starting material in academic and industrial labs focused on developing new fluorination methodologies and studying structure-activity relationships (SAR).

Basic Information

Product Name	2-Fluoro-4-(trifluoromethyl)benzonitrile
CAS No.	146070-34-0
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-p-tolunitrile; 4-Cyano-3-fluorobenzotrifluoride; 2-Fluoro-4-(trifluoromethyl)phenyl cyanide; 3-Fluoro-4-cyanobenzotrifluoride; Benzonitrile, 2-fluoro-4-(trifluoromethyl)-; 146070-34-0; 2-Fluoro-4-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-4-(trifluoromethyl)benzonitrile is produced and tested under a strict quality management system. We ensure high purity and consistency to meet the exacting standards of research and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.