Description

4-Chloro-3,5-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for introducing the unique electronic and steric properties of the chloro-difluoro-substituted phenyl ring into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a halogenated, electron-deficient aromatic core.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the chloro and fluoro substituents enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and stability.
• Organic Electronic Materials: Employed in the research and production of organic semiconductors, OLEDs, and other electronic materials due to its electron-withdrawing character.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The activated fluorine atoms allow for selective substitution, enabling the introduction of various amines, alkoxides, and thiols.
• Cyanohydrin & Amide Formation: The nitrile group can be further functionalized to carboxylic acids, amides, tetrazoles, and other heterocycles.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	4-Chloro-3,5-Difluorobenzonitrile
CAS No.	144797-57-9
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	3,5-Difluoro-4-chlorobenzonitrile; 4-Chloro-3,5-difluorobenzene-1-carbonitrile; Benzonitrile, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluorophenyl cyanide; 2,6-Difluoro-4-cyanochlorobenzene; 144797-57-9; NSC 405124
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.