Description

Seco-Duocarmycin Sa is a potent synthetic derivative of the duocarmycin family of antitumor antibiotics, known for its sequence-selective DNA alkylation properties. This compound is a critical advanced intermediate and a powerful research tool for investigating novel cancer therapeutics and targeted drug delivery systems. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and the development of antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel duocarmycin-based cytotoxins for cancer therapy.
• Antibody-Drug Conjugate (ADC) Payloads: Used in the development of targeted cancer treatments, where its potent DNA-damaging activity is harnessed.
• Mechanistic Studies: A vital tool for studying DNA minor groove alkylation, sequence specificity, and the biochemical pathways of apoptosis induction.
• Preclinical Evaluation: Employed in in vitro and in vivo models to assess the efficacy and therapeutic window of new anticancer agents.
• Chemical Biology Probes: Used to design and synthesize probes for understanding cellular responses to DNA damage.
• Process Chemistry & Scale-Up: Acts as a reference standard and building block for optimizing synthetic routes in pilot and manufacturing scales.

Basic Information

Product Name	Seco-Duocarmycin Sa
CAS No.	144667-38-9
Molecular Formula	C30H35N3O7
Molecular Weight	549.62 g/mol
Synonyms	Seco-Duocarmycin SA; (1S,8S,14S,21S)-14-[(Cyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-yl)carbonyl]-1,8,21-trimethyl-10,19-dioxa-4,13-diazatetracyclo[13.7.1.03,13.07,12]tricosa-3,5,7,9,11-pentaene-2,9,12,20-tetrone; Duocarmycin SA Seco Drug; CC-1065 Analog; DNA Alkylating Agent
EINECS	Contact for details

Quality Control

Our Seco-Duocarmycin Sa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep under ventilation and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.