Description

1-Bromo-5-Fluoro-2-Iodo-3-Nitrobenzene is a high-purity, multi-halogenated nitrobenzene derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an invaluable scaffold for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where precise halogen placement is key to modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by introducing halogenated aromatic cores into lead compounds.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Versatile electrophile in metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution for introducing complex functionalities.
• Dye & Pigment Industry: Intermediate for synthesizing specialized halogenated dyes and pigments with enhanced lightfastness and color properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and for creating focused libraries for high-throughput screening.

Basic Information

Product Name	1-Bromo-5-Fluoro-2-Iodo-3-Nitrobenzene
CAS No.	144580-17-6
Molecular Formula	C6H2BrFINO2
Molecular Weight	345.89 g/mol
Synonyms	2-Bromo-4-fluoro-1-iodo-5-nitrobenzene; 3-Nitro-1-bromo-5-fluoro-2-iodobenzene; 5-Fluoro-2-iodo-3-nitro-1-bromobenzene; Benzene, 1-bromo-5-fluoro-2-iodo-3-nitro-; 144580-17-6; 1-Bromo-5-fluoro-2-iodo-3-nitrobenzene; 2-Iodo-5-fluoro-3-nitro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Fluoro-2-Iodo-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high batch-to-batch consistency and reliable supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.