Description

Pixantrone is a synthetic aza-anthracenedione derivative and a potent topoisomerase II inhibitor with significant antitumor activity. This compound is valued for its distinct mechanism of action and reduced cardiotoxicity profile compared to earlier anthracycline analogs, making it a critical entity in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on oncology drug discovery and the development of novel chemotherapeutic agents.

Application

• Oncological Research: A key investigational agent for studying novel cancer therapies, particularly for non-Hodgkin's lymphoma and other hematological malignancies.
• Pharmaceutical Development: Serves as an active pharmaceutical ingredient (API) in the formulation and clinical development of new chemotherapeutic drugs.
• Mechanistic Studies: Used in biochemical and pharmacological research to investigate topoisomerase II inhibition and DNA intercalation mechanisms.
• Preclinical Evaluation: Employed in in vitro and in vivo models to assess antitumor efficacy, pharmacokinetics, and safety profiles.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory compliance in API manufacturing.
• Combination Therapy Research: Investigated for potential synergistic effects when used in combination with other anticancer agents.

Basic Information

Item	Detail
Product Name	Pixantrone
CAS No.	144510-96-3
Molecular Formula	C17H19N5O2
Molecular Weight	325.37 g/mol
Synonyms	Pixantrone dimaleate (salt form); BBR 2778; 6,9-Bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione; Benzo[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-; Pixantrone maleate; BBR-2778; DB 2778; UNII-4V295UJ1S8
EINECS	Contact for details

Quality Control

Our Pixantrone is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.