Description

Landiolol Hydrochloride is a highly selective, ultra-short-acting β-1 adrenergic receptor antagonist. This compound is of significant value in clinical and pharmaceutical research due to its rapid onset and offset of action, making it a critical agent for precise cardiovascular control. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of injectable cardiovascular therapeutics and anesthesia adjuvants.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable solutions for rapid heart rate control.
• Clinical Research: Used in studies investigating the management of intraoperative and perioperative tachycardia and myocardial ischemia.
• Drug Development: Serves as a reference standard and a key intermediate in the synthesis of novel β-blocker derivatives.
• Anesthesiology: Employed as an adjunct to anesthesia to stabilize heart rhythm during surgical procedures.
• Cardiovascular Pharmacology: A vital tool for in vitro and in vivo studies of β-1 adrenergic receptor function and cardiac electrophysiology.
• GMP Manufacturing: Supplied as a high-purity raw material for the commercial production of finished dosage forms under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Landiolol Hydrochloride
CAS No.	144481-98-1
Molecular Formula	C25H36N2O4 • HCl
Molecular Weight	465.03 g/mol
Synonyms	Onoact 50; Landiolol HCl; (S)-(-)-4-[2-Hydroxy-3-[[2-[4-(2-methoxyethyl)phenoxy]ethyl]amino]propoxy]benzenepropanamide Hydrochloride; ONO-1101; 2-Propanamide, 4-[2-hydroxy-3-[[2-[2-(2-methoxyethoxy)phenoxy]ethyl]amino]propoxy]-N-methyl-, hydrochloride, (2S)-; Landiololum; Landiolol (Hydrochloride); Landiolol Hydrochloride (JP17)
EINECS	Contact for details

Quality Control

Our Landiolol Hydrochloride is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, with a focus on compliance with pharmacopeial guidelines such as JP (Japanese Pharmacopoeia). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing all specified tests and results, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	-10.0° to -12.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.