Description

2-Butenenitrile,3-(4-Fluorophenyl)-,(Z)-(9Ci) is a specialized fluorinated nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate, enabling the construction of complex molecules with high stereochemical fidelity. Pharmaceutical and agrochemical research organizations need it for the development of novel active ingredients, particularly where the (Z)-alkene configuration and the fluorophenyl moiety are critical for biological activity and metabolic stability. Its precise structure offers a versatile handle for further functionalization in multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of chiral drug candidates, especially in therapeutic areas targeting the central nervous system (CNS) and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom enhances bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers for advanced polymers with specific optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for creating labeled compounds and molecular probes to study biological pathways.

Basic Information

Item	Details
Product Name	2-Butenenitrile,3-(4-Fluorophenyl)-,(Z)-(9Ci)
CAS No.	144477-79-2
Molecular Formula	C10H8FN
Molecular Weight	161.18 g/mol
Synonyms	(Z)-3-(4-Fluorophenyl)-2-butenenitrile; (Z)-3-(p-Fluorophenyl)but-2-enenitrile; (Z)-2-Butenenitrile, 3-(4-fluorophenyl)-; 3-(4-Fluorophenyl)-2-butenenitrile (Z)-isomer; (Z)-3-(4-Fluorophenyl)crotononitrile; (Z)-p-Fluorophenylcrotononitrile; (Z)-β-Methyl-p-fluorocinnamonitrile
EINECS	Contact for details

Quality Control

Our 2-Butenenitrile,3-(4-Fluorophenyl)-,(Z)-(9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including chiral purity verification by HPLC and structural confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor quality documentation to meet specific regulatory or research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged procedures to maintain stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (Z)-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.