Description

Rofleponide CAS NO 144459-70-1 is a synthetic corticosteroid compound belonging to the glucocorticoid class. This active pharmaceutical ingredient (API) is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical component in advanced pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of inhalation therapies for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Application

• Primary Active Pharmaceutical Ingredient (API) in metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) for asthma management.
• Key component in combination inhalation therapies for chronic obstructive pulmonary disease (COPD).
• Used in pharmaceutical research and development for novel respiratory drug delivery systems.
• Reference standard in analytical laboratories for quality control and method validation.
• Intermediate in the synthesis of more complex corticosteroid derivatives.
• Subject of clinical studies investigating topical anti-inflammatory applications.

Basic Information

Product Name	Rofleponide
CAS No.	144459-70-1
Molecular Formula	C₂₇H₃₇FO₆
Molecular Weight	476.58 g/mol
Synonyms	Rofleponide; (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic acid S-fluoromethyl ester; 17α-[(Fluoromethyl)thio]carbonyl]-6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-11β-carbothioate; ZK-91296; Rofleponide Palmitate (pro-drug form)
EINECS	Contact for details

Quality Control

Our Rofleponide is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting the stringent requirements for an Active Pharmaceutical Ingredient (API). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support our partners with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.