Description

2-Fluoro-5-Hydroxy-L-Tyrosine Hydrochloride is a fluorinated derivative of the amino acid L-tyrosine, specifically modified to serve as a key building block in advanced pharmaceutical research and development. This compound matters because its unique structure, incorporating a fluorine atom at the 2-position, is critical for modulating biological activity, stability, and metabolic pathways in novel drug candidates. It is primarily needed by research scientists and process chemists in the pharmaceutical and biotechnology industries for the synthesis of potential therapeutics targeting neurological disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel fluorinated drug candidates, particularly for central nervous system (CNS) targets.
• Biochemical Research: Used as a probe or substrate in enzymatic studies to investigate tyrosine metabolism and fluorinated amino acid incorporation.
• Peptide Synthesis: Serves as a specialized, fluorinated amino acid residue for constructing modified peptides with enhanced stability or specific receptor affinity.
• Radiopharmaceutical Development: Potential use as a precursor for F-18 labeled compounds in Positron Emission Tomography (PET) imaging agent research.
• Metabolite Analog Studies: Employed in metabolic pathway analysis to study the effects of fluorinated analogs of natural biochemicals.

Basic Information

Product Name	2-Fluoro-5-Hydroxy-L-Tyrosine Hydrochloride
CAS No.	144334-59-8
Molecular Formula	C9H11FNO4 • HCl
Molecular Weight	251.65 g/mol (Free base: 215.19)
Synonyms	L-2-Fluoro-5-hydroxytryosine HCl; (2S)-2-Amino-3-(2-fluoro-5-hydroxyphenyl)propanoic acid hydrochloride; 2-F-5-OH-L-Tyr•HCl; 2-Fluoro-5-hydroxy-DL-tyrosine hydrochloride (racemic mixture); 2-Fluoro-5-hydroxyphenylalanine hydrochloride; F-5-OH-Tyr HCl; 144334-59-8; 2-Fluoro-5-hydroxy-L-phenylalanine HCl
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Hydroxy-L-Tyrosine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.