Description

18-Hydroxycortisol (Hemiacetal) is a significant steroid metabolite and synthetic intermediate of high interest in pharmaceutical research and development. This compound is crucial for its role in the study of steroid hormone biosynthesis and metabolism, particularly in relation to adrenal function. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel corticosteroids and the investigation of endocrine pathways.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development and validation in quality control laboratories.
• Biochemical Research: Serves as a key intermediate or substrate in studies of cortisol metabolism, 11β-hydroxysteroid dehydrogenase activity, and adrenal disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: An important building block in the multi-step synthesis of more complex corticosteroid analogs and drug candidates.
• Diagnostic Development: Employed in the development and calibration of immunoassays and LC-MS/MS methods for clinical diagnostics related to adrenal function.
• Metabolite Studies: Used in in vitro and in vivo studies to understand the metabolic fate and biological activity of cortisol derivatives.

Basic Information

Product Name	18-Hydroxycortisol (Hemiacetal)
CAS No.	144302-17-0
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	18-Hydroxycortisol; 11β,17α,21-Trihydroxy-18-oxopregn-4-ene-3,20-dione hemiacetal; 18-Oxocortisol hemiacetal; 18-Hydroxycortisol cyclic 18,20-hemiacetal; 18-OHF; 18-Hydroxycorticosterone metabolite
EINECS	Contact for details

Quality Control

Our 18-Hydroxycortisol (Hemiacetal) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and specific tests for residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications and results are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.